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Mimetix® Multi-Well Plate

 

3D cell culture in a scaffold of polymer fibres

 

Mimetix® scaffolds for 3D cell culture: Mimetix® scaffolds are highly porous and mimic the extracellular matrix, providing an ideal environment to support the growth of cells in 3D.  They are created by electrospinning the medical grade polymer poly-L-lactide (PLLA) into fibres.  The Mimetix® scaffold is highly consistent well-to-well with respect to fibre diameter and pore size, resulting in excellent reproducibility of cell-based assays.

 

Mimetix® has been validated with a number of primary cells, cell lines and stem cells and is available in a range of ready to use, sterile laboratory consumable formats.

 

 

Why Use 3D Models in Drug Discovery?

 

Cells grown in a 3D micro-environment look and behave more like cells in human tissues than those cultured in 2D.  They are in contact with other cells and produce extracellular matrix, which influences tissue-specific gene expression, cell growth, and the uptake and metabolism of drugs. 3D cell-based in vitro assays can provide more realistic data on the efficacy of drug candidates against tumour cells or their toxicity, and could potentially reduce the risk of failure in expensive clinical trials.

 

MCF7 breast cancer cells growing within the Mimetix™ scaffold

 

Mimetix® multiwell plate

 

The 96 well plate is based on the successful Vision Plate range with superior optical clarity of the base and laser welding technology to weld bases to the frame with minimal base distortion and no use of cytotoxic glues.  It contains the Mimetix® scaffold laser-welded into the base, and is designed to be compatible with industry standard for automated handling and imaging equipment.  It is available in fibre diameters of 2 μm and 4 μm, corresponding to pore sizes of 10-18 μm and 15-31 μm and at a scaffold thickness of 50 μm.  It is supplied gamma-irradiated in individually sealed plastic wrapping.

benefits

• Mimetix® benefits in 3D assays

• True 3D environment high batch

  -to-batch consistency for

  reproducible cell-based assays.

• Ready to use, sterile, standard

  size plates are compatible with

  industry standard automated

  handling & imaging equipment.

• Minimal protocol adaption

  required to switch from 2D to 3D.

• Material does not degrade or

  alter over the course of an

  experiment.

• Thin scaffold provides benefits of

  3D cell morphology & behaviour

  yet allows fluorescent

  microscopic imaging.

Mimetix® scaffold resembles the extracellular matrix.

Code

Description

Plates / case

4ti-0250/2

4ti-0250/4

96 well plate with fibres of 2 μm diameter

96 well plate with fibres of 4 μm diameter sterile, lidded

8

8

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