Mimetix® scaffolds for 3D cell culture: Mimetix® scaffolds are highly porous and mimic the extracellular matrix, providing an ideal environment to support the growth of cells in 3D. They are created by electrospinning the medical grade polymer poly-L-lactide (PLLA) into fibres. The Mimetix® scaffold is highly consistent well-to-well with respect to fibre diameter and pore size, resulting in excellent reproducibility of cell-based assays.
Mimetix® has been validated with a number of primary cells, cell lines and stem cells and is available in a range of ready to use, sterile laboratory consumable formats.
Cells grown in a 3D micro-environment look and behave more like cells in human tissues than those cultured in 2D. They are in contact with other cells and produce extracellular matrix, which influences tissue-specific gene expression, cell growth, and the uptake and metabolism of drugs. 3D cell-based in vitro assays can provide more realistic data on the efficacy of drug candidates against tumour cells or their toxicity, and could potentially reduce the risk of failure in expensive clinical trials.
The 96 well plate is based on the successful Vision Plate range with superior optical clarity of the base and laser welding technology to weld bases to the frame with minimal base distortion and no use of cytotoxic glues. It contains the Mimetix® scaffold laser-welded into the base, and is designed to be compatible with industry standard for automated handling and imaging equipment. It is available in fibre diameters of 2 μm and 4 μm, corresponding to pore sizes of 10-18 μm and 15-31 μm and at a scaffold thickness of 50 μm. It is supplied gamma-irradiated in individually sealed plastic wrapping.
• Mimetix® benefits in 3D assays
• True 3D environment high batch
-to-batch consistency for
reproducible cell-based assays.
• Ready to use, sterile, standard
size plates are compatible with
industry standard automated
handling & imaging equipment.
• Minimal protocol adaption
required to switch from 2D to 3D.
• Material does not degrade or
alter over the course of an
• Thin scaffold provides benefits of
3D cell morphology & behaviour
yet allows fluorescent
Mimetix® scaffold resembles the extracellular matrix.
Plates / case
96 well plate with fibres of 2 μm diameter
96 well plate with fibres of 4 μm diameter sterile, lidded
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